Advances in reciprocal regulation mechanisms of microRNAs and target genes
نویسندگان
چکیده
منابع مشابه
MicroRNAs preferentially target the genes with high transcriptional regulation complexity.
Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal genomes at post-transcriptional level. However, it is still unclear why some genes are regulated by miRNAs but others are not, i.e. what principles govern miRNA regulation in animal genomes. In this stu...
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MeCP2 encodes a methyl-CpG-binding protein that plays a critical role in repressing gene expression, mutations of which lead to Rett syndrome and autism. PTEN is a critical tumor suppressor gene that is frequently mutated in human cancers and autism spectrum disorders. Various studies have shown that both MeCP2 and PTEN proteins play important roles in brain development. Here we find that MeCP2...
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ژورنال
عنوان ژورنال: Chinese Science Bulletin
سال: 2021
ISSN: 0023-074X
DOI: 10.1360/tb-2020-1581